Mesoamerica, an archaeological culture area in the Americas within which a number of pre-Columbian societies flourished before colonization by the Spanish

Central America

Mesoamerican Linguistic Area, a defined linguistic area or sprachbund comprising numerous indigenous languages in Mesoamerica that exhibit certain similarities

Middle America (Americas), a wider region in the mid-latitudes of the Americas

Mesoamerican Biological Corridor, a biodiversity conservation initiative formed in 1997 to interconnect a number of protected areas in Mesoamerica