Mandrake, an electronic device in Kurt Vonnegut's novel Galápagos

The Mandrake, a play written by Niccolò Machiavelli

Group Captain Lionel Mandrake, a character in Stanley Kubrick's film Dr. Strangelove.

Mandrake, a monster from the Final Fantasy game series

Mandrake, the short-lived mascot at the University of Oregon, intended to replace the mascot which shares its likeness with Donald Duck

Mandrake (pesticide), a pesticide for wheat, commercialized by Bayer

Mandrake the Magician, a comic strip character

Mandrake Linux, the former name of Mandriva Linux, a Linux-based operating system

Mandrake (plant), a plant of the genus Mandragora

Mandrake (TV series), an original TV series from HBO Latin America (Brazilian branch)

MANDRAKE, a 1970's Japanese band that included Susumu Hirasawa

Mandrake of Oxford, a small press

Mandragora (demon), familiar demons (mandrakes)

Mandrake Press, a publishing company

Mandrake (album), an album by Edguy, released in 2001

Leon Mandrake, a magician (1911 - 1993)

Tom Mandrake, a comic book artist