Major League Baseball, the highest level of play in professional baseball in N. America.

Major North American professional sports leagues, an overview of major league sports in North America

Major League Soccer, the highest level of play in professional soccer in N. America.

Major League (film), a 1989 baseball movie

Major League II, a 1994 baseball movie, the second installment in the series

Major Indoor Soccer League the highest level of play in professional indoor soccer in the U.S.

Major League Lacrosse, the highest level of play in professional field lacrosse in the U.S.

Major League: Back to the Minors, a 1998 baseball movie, the third installment in the series

Major League Hockey, formerly the Ontario Hockey Association (OHA) Senior league; the top level of amateur men's ice hockey in Canada.

Major League Cricket, unofficially, the highest level of play in professional cricket in the U.S.

Major League Gaming, a professional league dedicated to competition in console gaming in the U.S.

Major League, A song from Pavement's their 1999 album Terror Twilight

Major League Wrestling, was a popular professional wrestling promotion that described itself as hybrid wrestling.

Major League Online, an online computer gaming league.

Tonga Major League, the highest level of play in professional footballl (soccer) in Tonga.

Major League Volleyball, formerly, the highest level of play in women's professional volleyball in the U.S.

Major Leagues (EP), Pavement's final EP