Mainframe is the city that the CGI cartoon ReBoot takes place in.

A character in the G.I. Joe universe.

Mainframe computer, large data processing systems

Mainframe (band), a 1980s Electropop band

Mainframe Entertainment, a Canadian computer animation and design company.

A character from the game Gunman Chronicles.

Mainframe is the name of two fictional characters from Marvel Comics

Mainframe (comics) appears in the series A-Next

Mainframe appears in the Guardians of the Galaxy series

Mainframe (Transformers) is An Autobot character in the Transformers series.