Madonna (entertainer), American singer and actress

Mary (mother of Jesus), from which all other uses ultimately derive

Black Madonna, a statue or painting of Mary in which she is depicted with black skin

Madonna (art), a portrait of Mary

"Lady Madonna", a song by The Beatles

Madonna (Madonna album), her self-titled debut album

Madonna Wayne Gacy, stage name of Stephen Gregory Bier Jr, keyboard player for Marilyn Manson

Madonna of the Trail, a series of historical monuments from Maryland to California

Madonna University, a college in Livonia, Michigan

Madonna piercing, a type of facial piercing that can resemble a mole

"Black Madonna", a song by Noe Venable

House of the Black Madonna, a cubist building in Prague, Czech Republic

Madonna Inn, a resort hotel in California

Madonna and Child, portraits of Mary and the infant Christ

Madonna (Edvard Munch), a painting by Edvard Munch

Madonna Oriente, a moon goddess

Madonna (Trail of Dead album)

Madonna lily, a plant in the genus Lilium

Madonna del Ghisallo, a hill close to Lake Como in Italy

Madonna (skateboarding trick)

Madonna, the top F1 team in the video games Super Monaco GP and Ayrton Senna's Super Monaco GP II