In sports, Major League Eating. [1]

In broadcast, multi-layered effects.

The Master in Law and Economics degree offered by IMADEC University.

In statistics, maximum likelihood estimator.

In e-learning, Managed Learning Environment.

In research, Media Lab Europe.

In molecular biology, Muconate lactonizing enzyme.

Marxistisk-Leninistisk Enhedsforbund, a Danish Maoist group 1972-1975.

Additionally, MLE is the IATA Code for Malé International Airport.