Lucrezia Borgia was the name Buffalo Bill gave to his gun.

Lucretia, a mythical figure in the history of the Roman Republic

Lucrezia Borgia, the daughter of Rodrigo Borgia, who became Pope Alexander VI

Lucrezia Borgia is an opera by Gaetano Donizetti.

Lucrezia Noin, a character from the anime Gundam Wing.

Lucrezia d'Alagno, a close acquaintance of Alfonso V of Naples.

Several women named Lucrezia de' Medici.

Lucrezia (singer), a female Italian singer.