John Locke, an English Enlightenment philosopher

John Locke (Lost), a character in the television series Lost

Locke, a pseudonym of Peter Wiggin, a character in the novels by Orson Scott Card

Locke the Echidna, a character in the Sonic the Hedgehog series

Locke, a main character of the manga Locke the Superman

Locke, New York, a town in Cayuga County, New York

Locke, California, a town in Sacramento County, California

Locke Township, Michigan, is a township located in Ingham County, Michigan

Locke High School, Los Angeles, California

Locke (surname), information about the surname and list of people

Mount Locke, in the Davis Mountains of West Texas