Least squares estimation

London Stock Exchange

London Stock Exchange Group plc

Luxembourg Stock Exchange

The London School of Economics and Political Science, specialist constituent college of the University of London

Language-Sensitive Editor, a text editor used on Digital Equipment Corporation's VMS operating system.

LSE (programming language), a programming language developed in France for minicomputer usage during the 1970s with influence from BASIC.

In Socionics, a Logical Sensory Extrovert.

The IATA airport code of the La Crosse Municipal Airport in La Crosse, Wisconsin, in the United States.