Large optical cavity (lasers)

Level of consciousness

Launch Operations Center (NASA)

Lines of code, a software metric used to measure the amount of code in a software program

Letter of comment

Library of Congress, the national library of the United States

Letter of credit

LeMoyne-Owen College, a historically black college located in Memphis, Tennessee

Lab-on-a-chip, a term for devices that integrate multiple laboratory functions on a single chip

Leftöver Crack, a Crack Rock Steady band

Loss of coolant accident, a mode of failure for a nuclear reactor

Lyric Opera of Chicago

Line of Control, a line which demarcates the boundary between the territories controlled by two militaries or political entities

Localizer, a component of an Instrument Landing System

Line of credit, a type of credit

Lines of communication, in the military

Liga Obrera Comunista,a Trotskyist group in Spain active from 1976-1990

Love of Crips, (Examples: Tone Loc, Spider Loc, etc.)