Knuckles the Echidna (comic character), Knuckles as he appears in the Sonic the Hedgehog comics.

Knuckles the Echidna (comic series), a comic book featuring Knuckles.

Knuckles the Echidna, a fictional character from the Sonic the Hedgehog series of video games, cartoons, and British comic series.

Knuckleball, a baseball pitch with wild movement that is thrown with the knuckles.

Knuckle (shipbuilding), a mechanism where the round projecting part of a hinge through which the pin is run, and in shipbuilding to an acute angle on some of the timbers.

Brass knuckles, a weapon used in hand-to-hand combat.

Cracking knuckles, manipulating the knuckle joints to produce a "cracking" sound.

Knuckles mountains, a mountain range in central Sri Lanka.

A knuckle is a joint on the hand. It may also refer to: