Jesse James was a nineteenth century American West outlaw. Other people named Jesse James include:

Jessie and James from Team Rocket, a fictional villainous and comic relief trio (Meowth is the third) from Pokemon

Brian Gerard James, a professional wrestler who has Jesse James as a stage name

The Assassination of Jesse James by the Coward Robert Ford, a 2007 film

Jesse James Hollywood, a criminal

Jesse G. James, a custom motorcycle builder, his distant cousin

Jesse James (1939 film), a 1939 film

Jesse James (band), a British punk band

Jesse James (actor), an actor