Richard Jefferies, English writer of journalism and fiction on the countryside

Gregg Jefferies (born 1967), American baseball infielder

Jim Jefferies, Scottish football manager of Kilmarnock F.C.

Matt Jefferies, aviation and mechanical artist, set designer and writer

Jefferies & Company, a global investment bank and institutional securities firm

Chris Jefferies (born 1980), American basketball player

Alan Jefferies, poet and children's author

Jefferies tube, a small tunnel or corridor that provides access to starship systems in Star Trek

Mark Jefferies, notorious bushranger, serial killer and cannibal in the early 19th century