Ixtlilxochitl can refer to a number of Mesoamerican nobles, including:

Codex Ixtlilxochitl, historical Mesoamerican document authored by Fernando de Alva Cortés Ixtlilxochitl

Ixtlilxochitl I, tlatoani (ruler) of the central Mexican city-state of Texcoco from 1409 to 1418.

Ixtlilxochitl II, placed on the throne of Texcoco by Hernan Cortés in 1520, and a great-grandson of Ixtlilxochitl I.

Fernando de Alva Cortés Ixtlilxochitl (1568? 1578? - c. 1650), an indigenous Mexican nobleman, historian and author, descendant of Ixtlilxochitl I and Ixtlilxochitl II.