Isaac Newton, physicist

Isaac Watts, hymn-writer

Isaac Asimov, writer

Yitzhak Rabin, prime minister of Israel

Major-General Sir Isaac Brock

Isaac Hanson, musician, guitarist of the band Hanson

Isaac Hayes, singer

Isaac Albéniz, composer

Yitzhak Shamir, prime minister of Israel

Isaac Singer, inventor

Isaac Stern, violinist

Itzhak Perlman, violinist

Ugonis, Henricus, Heinrich or Arrigo Issac or Ysaac, Franco-Flemish composer

Isaac Mizrahi, fashion designer

Chris Isaak, American musician

Isaac Brock (musician), lead singer of the band Modest Mouse

Isaac of Antioch, 5th century Christian writer

Isaac Isaacs, politician

Isaac of Nineveh, 7th century Christian writer

Sacrifice of Isaac (Caravaggio), two paintings by master artist Caravaggio depicting the Biblical scene of the binding of Isaac

Bobby Isaac, American racing driver

ISAAC (cipher), a cryptographically secure pseudorandom number generator.

Isaac Slade, lead singer of the band The Fray]

Glynn Isaac, South African archaeologist

Luis Isaac, Puerto Rican baseball player

John Isaac, English cricketer

Arthur Isaac, English cricketer

Robert M. Isaac, mayor of Colorado Springs

Oscar Isaac, American actor

Rhys L. Isaac, American historian

Isaac Smith (multiple people)

Isaac (TV show), his eponymous TV show on the Style Network

Isaac, Itzhak or Yitzhak (Hebrew: יִצְחָק, Standard Yiẓḥaq Tiberian Yiṣḥāq ; Arabic: إسحٰق, ʾIsḥāq ; "he will laugh") is one of the patriarchs, whose story is told in the Biblical book of Genesis. (See also Binding of Isaac for the narrative of Abraham's near-sacrifice of Isaac). Isaac is a given name, popular in both Christian and Jewish societies, generally in reference to the above. Izzy is also a short-form of the name Isaac. Famous people named "Isaac" include: