Dwight D. Eisenhower, popularly known as "Ike".

Ike (pronounced "EE-kay") Hayato, Yuji Sakai's best friend in Shakugan no Shana.

Chicago's Eisenhower Expressway, the main east-west expressway through the city, also known as The Ike.

Ike Turner

Internet key exchange, a key agreement protocol.

Ike, shortened, or nick-name for Isaac, Isaak or Ikechi (meaning "God's Strength" in Igbo). Isaac is Hebrew for the verb to laugh.

Ike Broflovski, a fictional character in South Park.

Ike, the main character in the GameCube game Fire Emblem: Path of Radiance.

Ike Anwhistle from A Series of Unfortunate Events.

A nickname for the main probe(Issac Newton) from Alien Planet