Inventory of Depressive Symptomatology or Inventory of Depressive Symptoms, a rating scale for clinical depressions

Interdictor/Strike, used to describe a fighter aircraft role

Iain Duncan Smith, a British politician

Integrated Deepwater System Program, a program to upgrade ships and other systems of the United States Coast Guard

Boeing Integrated Defense Systems, a division of the Boeing Company

Istrian Democratic Assembly (Istarski demokratski savez), a political party in Croatia

Intrusion detection system, a software system that detects unwanted manipulations to systems

Institute of Development Studies, a British organisation for research, teaching and communications on international development

Indiana Daily Student, Indiana University's Student Newspaper

Integrated Data Store, one of the first database management systems (DBMS) from the 1960s

Informix Dynamic Server, a relational database management system (RDBMS) sold by IBM

Information disclosure statement, a disclosure of relevant background art to the United States Patent and Trademark Office by an applicant for a patent (pertaining to the field of patent prosecution)

IDS Center, the tallest building in Minneapolis, Minnesota

Investors Diversified Services, now Ameriprise Financial, Inc., the original occupiers of the Minneapolis building

Raytheon Integrated Defense Systems, a division of Raytheon Company.