Homestead Strike, an 1892 labor confrontation at the Carnegie Steel Company in Homestead, Pennsylvania

Homestead Act, an 1862 United States Federal law that gave away millions of acres to farmers

Homestead Air Reserve Base, an U.S. Air Force base near Miami, Florida

Homestead, Florida

Homestead, Pennsylvania

Homestead-Miami Speedway, an auto racing track in Homestead, Florida

Homestead (novel), a 1998 novel by American writer Rosina Lippi

Homestead exemption, a legal regime to protect the value of a residence from expenses arising from the death of a spouse

The Homestead at Denison University, a student-run intentional community in Granville, Ohio

Homestead (area), an area measure of 160 acres (650,000 m²) also called a quarter-section

The Homestead, Virginia, a luxury resort in Hot Springs, Virginia

Homestead (buildings), a smallholding farm with a farmer's residence

Homestead principle, a legal concept that one can establish ownership of previously unowned property through use

Homestead, Wisconsin

Homestead, Missouri

Homestead Technologies, a web-hosting service based in Menlo Park, California

Homestead Records, a record label founded in 1983 and based in New York City

Homestead (small African settlement), a cluster of several single-family houses in southern Africa

Homesteading, a lifestyle of agrarian self-sufficiency

Homestead, Iowa

Homestead, Oklahoma

Homestead High School, the name of several high schools in the United States

Homestead Records (1920s), an American record company that flourished in the 1920s

The Homestead (Geneseo), a historic house in Geneseo, New York