Hombre, a 1961 novel by Elmore Leonard

Hombre, the Spanish word for "man" and sometimes used informally in English, may refer to:

L'Hombre (or, in 17th Century Spanish orthography, Ombre), a card game of Spanish origin

Hombre chipset for Commodore-Amiga computers.

Hombre, a 1967 motion picture based on the novel starring Paul Newman and directed by Martin Ritt

Hombre, a Spanish comics series by Antonio Segura and José Ortiz

The Hombres, a Memphis, Tennessee rock group who had a hit in 1967 with "Let It Out (Let It All Hang Out)"