Thomas Gainsborough, a painter (who is often referred to simply as Gainsborough)

Gainsborough Pictures, a London-based film studio, active between 1924 and 1951

Gainsborough Trinity F.C.

Humphrey Gainsborough, Thomas's brother

Gainsborough Riverside Festival

Gainsborough, Lincolnshire, England

The Gainsborough estate in Ipswich, England

Gainsborough Area in Kiama Downs, New South Wales, Australia

Aerith Gainsborough, a character from Final Fantasy VII

Gainsborough (horse), the 1918 Triple Crown Champion of English Thoroughbred Racing

HMS Gainsborough, a Royal Navy ship