First Bank, formerly First Bank & Trust in St. Louis, Missouri

First Bank & Trust Company of Abingdon, Virginia with branches in Tennessee and Virginia

FirstBank Holding Company, also known as 1stBank, a privately held bank based in Colorado with locations in Colorado, California, and Arizona

First Bank of Lexington, Tennessee a privately held bank.

First Bank is the name used by various financial institutions worldwide. The term, either as whole or as part of a combination of names, may refer to:

FirstCaribbean International Bank, in Barbados

First Trust Bank, part of the AIB Group, in Belfast, Northern Ireland

First Bank of Nigeria, in Nigeria

First Gulf Bank, in Abu Dhabi, United Arab Emirates

First American National Bank, a defunct bank now part of Amsouth Bancorporation

First BanCorp, more commonly known as FirstBank, a financial holding company in Puerto Rico

Security First Network Bank, claimed to be the first pure internet bank, in Atlanta, Georgia

First Micro Finance Bank, in Karachi, Sindh, Pakistan

First International Bank, in Watford City, North Dakota

First Interstate Bank, a name used by various banks worldwide

Afriland First Bank, in Cameroon, Equatorial Guinea, Congo (Brazzaville) and Sao Tome e Principe

First National Bank, a name used by various banks worldwide

First Midwest Bank, in Joliet, Illinois

First Pacific Bank, a former bank based in Hong Kong

First Dawood Islamic Bank, in Karachi, Sindh, Pakistan

First Market Bank, in Richmond, Virginia