People with the surname Escher include:

M. C. Escher (1898-1972), a Dutch graphic artist

Esher (Myst), a character in Myst V: End of Ages

Alfred Escher (1819-1882), a Swiss politician and railway pioneer

"Escher" (song), a song by Teenage Fanclub from their 1993 album Thirteen

Josef Escher (1885-1954), a Swiss Federal Councilor

Arnold Escher von der Linth, a Swiss geologist