English as a second dialect, see English language learning and teaching

Estimated standard deviation, a statistical parameter

Education for Sustainable Development

Electrostatic discharge

Energy spectral density, a measure of the spectrum of a signal.

Episcopal School of Dallas, a school in Dallas, Texas

Electronic services delivery

Educational Service Districts

Examination Support Document, a type of document submitted to the USPTO in the patent application process.

Electrostatic sensitive device

Enlightened Sound Daemon (also known as EsounD or ESD)

Electronic software distribution

Ecologically sustainable development

Engineering Society of Detroit

Equivalent spherical diameter