Emergency Detection System, a component of NASA's Apollo Spacecraft used to automatically trigger an abort during the launch sequence.

Electrodynamic suspension, a type of magnetic levitation

Electronic Data Systems, a Global Information Technology services company

Ehlers-Danlos syndrome, a group of heritable connective tissue disorders

Energy-dispersive X-ray spectroscopy, a method used to determine the energy spectrum of X-ray radiation

Earth Departure Stage, a rocket stage forming part of NASA's project Constellation

Excessive Daytime Sleepiness, a sleep disorder symptom, specially common in Sleep Apnea and Narcolepsy

Extended Data Services (now XDS), a standard for the delivery of metadata on NTSC video signals

Educational Specialist (Ed.S.), a terminal academic degree in the U.S.

European Democrat Students, a Christian Democratic students union

Electronic Document System, an early graphical hypertext system

Environmental Defence Society, a New Zealand environmental organisation

Episcopal Divinity School, an Episcopal Seminary in Cambridge, Massachusetts

Evansville Day School, an independent college-prep school in Evansville, Indiana

Explosive Detection System, a mechanism for detecting explosive material