Eugene Christian Fellowship, a large church in Eugene, Oregon

Extracellular fluid, a medical term

Electronic Case Filing System, an automated system for prosecution of criminal offenses

English Chess Federation, the governing chess organisation in England

Economic Cooperation Foundation, a non-governmental entity in Israel

European Cyclists' Federation, an umbrella organisation for European cycling organisations

European Cultural Foundation, an independent European foundation

Epirubicin, Cisplatin, Fluorouracil, a chemotherapy regimen