Down and Out in Paris and London, a 1933 semi-autobiographical book by George Orwell

Down and Out in the Magic Kingdom, a 2003 science fiction novel by Cory Doctorow

Down and Out in Beverly Hills, a 1986 American comedy film

Down and Out in America, a 1986 documentary film on poverty in the USA

Down and Out is a passing play in American football where the quarterback passes to a pre-arranged wide receiver. Down and Out may also refer to:

a rap single by rapper Cam'ron, featuring Kanye West & Syleena Johnson, from his 2004 album Purple Haze