Relative direction, where down is the opposite of up

Down syndrome, a genetic disorder

Down (American football), in American/Canadian football, a period of time where one play takes place

County Down, a county within Northern Ireland

Downland, a type of hill

Down (band), an American southern heavy metal supergroup

"Down" (Pearl Jam song)

Down (Northern Ireland Parliament constituency)

Railroad directions, where down and up have locally significant meanings

"Down" (blink-182 song)

"Down" (Juelz Santana Song)

Down feather, a soft bird feather frequently used in manufacture of bedding.

Down (UK Parliament constituency)

"Down" (311 song)

Down payment, a term used in the context of the purchase of items

Down (comics), a comic book published by Top Cow Productions

Down (film), an English remake of the film De Lift, about an express elevator that develops a mind of its own

Down (The Jesus Lizard album)

"Down" (Rakim y Ken-Y song)

Down (Sentenced album)

Down (novel), a Bernice Summerfield novel by Lawrence Miles

"Down" (Stone Temple Pilots Song)

Down (game theory), a standard position in mathematical game theory