Desperate Remedies, novel by Thomas Hardy

Desperate Housewives, American television series

Desperate Dan, wild west character in the British comic The Dandy

Desperate Straights, album by British avant-garde rock groups Slapp Happy and Henry Cow

Desperate Living, 1977 film by Baltimore, Maryland, USA filmmaker John Waters starring Liz Renay

The Desperate Dan Book, DC Thomson publication

Desperate Measures, 1998 Action Thriller starring Michael Keaton

Desperate (film), 1947 suspense film directed by Anthony Mann

Desperate Bicycles, English punk group

Desperate (album), 1983 album by Divinyls

The Desperate Hours, a 1955 Humphrey Bogart film, and it's 1990 remake, Desperate Hours.