Desi Arnaz, a Cuban-born musician, actor, comedian and television producer

Desi is a self-referential term used by South Asian people. Desi may also refer to:

Desorption electrospray ionization, an ambient ionization technique for Mass Spectrometry

Desi Arnaz, Jr., an actor and musician

Desidae, a genus of spiders

Desi Relaford, a professional American baseball player

Drug Efficacy Study Implementation