Desdemona Stephanides, a character in the book Middlesex by author Jeffrey Eugenides

Desdemona, a character in the book Vurt by author Jeff Noon

Desdemona (Eddie Murphy song), a hit single sung by Eddie Murphy (Motown, 1993) (music)

Desdemona, a Jimmy Buffett song

Desdemona, a character in the animated TV series Gargoyles

Desdemona, a typeface included with early versions of Microsoft software, such as Office 4.3

Desdemona (Allman Brothers song), a song by The Allman Brothers

Desdemona, a rôle from Shakespeare's Othello in the film O, renamed Desi Brable, played by Julia Stiles (1999/2001)

Desdemona, a character in the book Trust Me by author Jayne Ann Krentz

Desdemona, a character in the book Eleven Hours by author Paullina Simons

Desdemona, a cat character in the comic strip Mutt and Jeff

Desdemona (moon), a moon of Uranus

Desdemona, a character recreated as Kynaston, played by Billy Crudup the film Stage Beauty

Desdemona, a character in the book The Midnighters by the author Scott Westerfeld

Desdemona Music Festival, music festival in Cincinnati, Ohio

666 Desdemona, an asteroid

Desdemona, a fictional character in a tale found in the Hecatommithi (1565) by Cinthio (Giovanni Battista Giraldi)

Desdemona (Othello), a fictional character in William Shakespeare's play Othello (1603)

Desdemona (Otello), a soprano role in Giuseppe Verdi's opera Otello (1887)

Desdemona (Marc Bolan song), a song first recorded by John's Children