René Descartes was a French mathematician and philosopher. Descartes may also refer to:

Descartes (crater), on the Moon

The Descartes Prize, the European prize for excellence in scientific research and science communication

University of Paris V: René Descartes, a university in Paris

Descartes, Indre-et-Loire, a commune of France

Descartes Editeur, a French game publishing company

Descartes (plotting tool), computer software