Down Syndrome

Nintendo DS, a handheld gaming device made by Nintendo

Citroën DS, a model of Citroën car

Bureau of Diplomatic Security, the law enforcement arm of the United States Department of State

Due Sicilie (Two Sicilies), a defunct kingdom composing of Southern Italy and the island of Sicily.

Democratici di Sinistra, the Democrats of the Left, a former Italian political party

Demokratska stranka, the Democratic Party (Serbia)

Duodenal switch, short for Bilio-Pancreatic Diversion with Duodenal Switch

Detective Superintendent (police), technically incorrect but sometimes seen

Digital Spy, an entertainment and media website

Air Senegal (IATA code)

Dielectric spectroscopy

D.S. (song), a song by Michael Jackson on his HIStory album

Darmstadtium, an atomic element

7.92 DS, a Polish-designed anti-tank ammunition type

Dal Segno, a navigation marker in music notation

Directional Symmetry, a method for time series analysis

Dark Sun, a frp setting for Dungeons and Dragons

Detective Sergeant, a rank within the British Criminal Investigation Department

Derek Sherinian, keyboardist

dS, an abbreviation for dwarf spiral galaxy (also see dwarf galaxy and spiral galaxy)

D/S - Domination and Submission (BDSM)