Dr. Dre, a rapper, producer, actor, and founder and CEO of Aftermath Entertainment

Disc Read Error, a type of disk storage error, in computing

DRE (Direct Recording Electronic) voting machine

André 3000, a rapper, hip hop producer and actor

Mac Dre, a deceased Vallejo based rapper who founded Thizz Entertainment

Doctor Dre, a radio personality and former MTV VJ

Digital rectal examination

Dre (producer), a Miami-based producer/rapper

Dresta, a rapper who worked with Eazy-E from 1993 until his death

Drug Recognition Expert

Distributed Real-time and Embedded, in distributed computing and real-time computing