Discrete event simulation, a simulation that models a system by examining its changes as discrete events

Data Encryption Standard, a deprecated cryptographic block cipher that falls to brute force attacks due to its short 56-bit key

Diethylstilbestrol, a synthetic estrogen developed to supplement a woman's natural estrogen production

Discipline Economiche e Sociali (Economics and Social Sciences); a degree course in economics held at Bocconi University.

Drug-eluting stent, a device placed in coronary arteries to treat or prevent heart attacks

Department of Education and Science, a former department in the United Kingdom government

Deep Ecliptic Survey, an astronomy project to find Kuiper belt objects

Detached eddy simulation, a turbulence model used in computational fluid dynamics

The Dark Energy Survey, a proposed survey of part of the Southern sky to determine cosmology parameters

Diffuse esophageal spasm, a condition resulting from a disorder of the esophagus

The musical note D♭, in German nomenclature

Delivered Ex Ship, an Incoterm

DirectShow Editing Services, a Microsoft DirectShow API.

Dysequilibrium syndrome, former name for VLDLR-associated cerebellar hypoplasia

A shortened form of the names Desmond and Desiree