Dewey Decimal Classification, often called the Dewey Decimal System

Dragon Dagger Super Poisoned, a weapon from the game of Runescape

Shin Megami Tensei: Digital Devil Saga, a 2004 PlayStation2 role-playing game and spinoff of the Shin Megami Tensei series.

Davao Death Squad, the monicker used to describe the killers of notorious criminals in Davao City

Deflation Detection System

Department of Driver Services, a motor vehicle agency in Georgia

Doctor of Dental Surgery, academic degree

Digital Data Storage, a storage tape format related to Digital Audio Tape (DAT)

Direct Digital Synthesis

Data Distribution Service

Dry Deck Shelter

Data Design System, DDS-CAD software vendor

DirectDraw Surface, .dds texture files

Disability Determination Service, a state agency in the United States that determines eligibility for federal disability benefits

Digimon Data Squad, season 5 of the Digimon anime

Distillers Dried Solubles, a cereal byproduct of the distillation process.