Anthony Comstock, (1844–1915), U.S. moral reformer and namesake of the Comstock laws

Comstock Lode and mines in Virginia City, Nevada

Gordon Comstock, a fictional character in George Orwell's novel Keep the Aspidistra Flying

Anna Botsford Comstock, (1854–1930), was a U.S. artist, educator, and conservationist

Comstock Tram at two locations in West Coast, Tasmania

Comstock Township, Minnesota

Comstock laws, anti-obscenity laws in the United States

Comstock Park, Michigan

Charles Carter Comstock (1818-1900), U.S. politician from Michigan

William Comstock (1877–1949), Governor of Michigan

Comstock, Minnesota

Comstock Township, Michigan

Comstock, Nebraska

Comstock Northwest, Michigan

Dorothy Comstock Riley (1924–2004) was a lawyer and judge from the U.S. state of Michigan

Comstock (crater), a lunar crater

USS Comstock (LSD-45), a dock landing ship of the United States Navy

Solomon Gilman Comstock (1842-1933), U.S. politician from Minnesota

Oliver Cromwell Comstock (1780-1860), U.S. politician from New York

Roger Comstock, a fictional character in Neal Stephenson's Baroque Cycle of novels

Harriet Theresa Comstock, American novelist and author of children's books

Keith Comstock, (born 1955), major league baseball player

John Henry Comstock, (1849–1931), U.S. entomologist, co-creator of the Comstock-Needham system

Comstock, Texas and the Comstock Independent School District