The Cleft, a novel by 2007 Nobel prize laureate Doris Lessing

The Cleft, a fictional location in Age of D'ni from the computer game Myst

Cleft lip and palate, a congenital deformity

A cleft sentence, a type of grammatical construction

A cleft chin, a dimple on the chin

The Cleft of venus as a part of the female genitalia, part of the clitoris

Cleft of the Rock, a Muslim site in Jerusalem