Childhood's End, a science fiction novel by Sir Arthur C. Clarke

"Childhood's End", a song by British heavy metal band Iron Maiden, appearing on their 1992 album Fear of the Dark

"Childhood's End", a song by progressive rock band Marillion, appearing on their 1987 album Misplaced Childhood

"Childhood's End" (Stargate Atlantis), an episode of the science fiction television series Stargate Atlantis

"Childhood's End" (Pink Floyd song), a song on the album Obscured by Clouds by Pink Floyd

"The Children's Night" / "Child Hood's End" an episode of the anime television series RahXephon