Cold Rolled Steel

Cornered Rat Software, a Texas based computer game software company

Coordinate Reference System, Map projection, used in map making

Constant returns to scale

Cockney rhyming slang

Camp Rising Sun

Computerized Registration System used in UP Diliman for enrollment and grades viewing

Central Reservation Systems, also know as a Computer reservations system, used by airlines, hotels, and rental car agencies.

Catholic Relief Services

Creation Research Society

Chinese restaurant syndrome

Caudal regression syndrome

Congressional Research Service

Controlled random search, a global optimization method

congenital rubella syndrome

Carrier Routing System

Crystal red shrimp

Cambridge Reference Sequence (used in mitochondrial DNA testing)

Calorie Restriction Society

Caudill Rowlett Scott, Architects, later known as CRS-Sirrine

Cytokine Release Syndrome

Can't Remember Shit Syndrome; see Memory loss

Canada Remote Systems, a now-defunct bulletin board system based in Toronto

NHS Care Records Service, known as NHS CRS is part of Connecting for Health of the English National Health Service

Child Rebel Soldier Group consisting of rappers Kanye West, Lupe Fiasco, and Pharell

Compagnies Républicaines de Sécurité, a French riot police

Co-operative Retail Services, a former co-operative society in the United Kingdom

Centre for Remote Sensing of Bharathidasan University in Tiruchi in India.

CRS is the ICAO airline designator for Comercial Aerea, Mexico