The Breakthrough Institute think tank [1].

Breakthrough: The first appearance in the solution flowing from an ion exchange unit of unadsorbed ions similar to those which are depleting the activity of the resin bed. Breakthrough is an indication that regeneration of the resin is necessary.

"Breakthrough," the television program of Rod Parsley

Breakthrough Collaborative, a multinational educational group.

Breakthrough (Transnistria), a political youth organization in Transnistria

Breakthrough (board game), an abstract strategy board game

Breakthrough Generations Study, a large study into the causes of breast cancer

Breakthrough (human rights) an organization in the U.S. and India that uses pop culture to advance human rights.

Breakthrough (military), a situation where an offensive force has broken an enemy defensive line and is rapidly expoiting the gap.

Breakthrough (Dutch political history), a Dutch political movement in the late 1940s.

Breakthrough (single), a CD single by Japanese singer Aya Hirano

Break Through (album), a studio album by japanese band B'z

The Breakthrough, an album by American singer Mary J. Blige

"Breakthrough", a song by Modest Mouse from their 1996 album This Is a Long Drive for Someone with Nothing to Think About

"The Breakthrough", a song by LL Cool J from his 1987 album Bigger and Deffer

"Breakthrough", a song by Richard Wright from his 1996 album Broken China

The word breakthrough is cited as a frequently-used buzzword, in which case its meaning is intentionally vague, but carries a connotation of newness or modernness. See buzzword for an explanation of this usage.