Bosco, the owner of Bosco's Inconvenience store in the Sam and Max series of computer games

Henri Bosco, a French writer

Hieronymus Bosch, a Flemish painter known in Spanish as El Bosco.

Bosko, an early Warner Brothers cartoon character

Castelnuovo Don Bosco a comune (municipality) in the province of Asti in the Italian region Piedmont named after Saint John Bosco.

Johannes de Sacro Bosco, an English scholar

The Sacro Bosco garden in Bomarzo.

Bosco Wong, a Hongkong actor

Bosco, an Irish children's television program

Bosco Sticks, a brand of cheese-filled breadsticks

Don Bosco Institute of Technology, Mumbai

Philip Bosco, an American actor

Juan Bosco Maino Canales, a Chilean political activist

João Bosco, a Brazilian singer

John Bosco Manat Chuabsamai, a Catholic bishop in Thailand

Jean Bosco Mwenda, a Congolese guitarist

Bosco Gurin, a German-speaking village in Switzerland.

Bosco Hogan, an Irish actor

Saint John Bosco (Don Bosco), Roman Catholic priest and founder of the Salesian Society

Bosconia a town in northern Colombia named after Saint John Bosco.

Officer Maurice 'Bosco' Boscorelli on the TV series Third Watch played by Jason Wiles

Bosco Chocolate Syrup, a drink mix and dessert topping referenced famously in Seinfeld

The name Bosco is also used by a Princeton, New Jersey based hip-hop DJ

St. John Bosco High School, Bellflower, California

Don Bosco Technical Institute, Rosemead, California

Don Bosco Preparatory High School, Ramsey, New Jersey

Don Bosco Technical College, Mandaluyong • Don Bosco Technical Institute, Makati • Don Bosco College, Canlubang • Don Bosco Technology Center, Cebu • Don Bosco School, Manila • Don Bosco Center for Studies, Parañaque • Don Bosco Technical Institute, Victorias • Don Bosco Technical Institute, Tarlac • Don Bosco Academy, Pampanga • St. Louis School – Don Bosco, Dumaguete • Don Bosco High School – Immaculate Conception Catholic School, Sta. Cruz • Caritas Don Bosco School, Sta. Rosa Provincial Houses: Philippines North (SDB) • Philippines South (SDB) • Philippines (FMA)

BOSCO may also refer to British people Of Sub-Continental Origin