William S. Burroughs (1914–1997), American novelist and essayist, who used 'Bill Lee' as a pen name and for several characters

Bill Lam Lee, acting assistant attorney general for civil rights in the Clinton Administration.

Bill Lee (left-handed pitcher) (born 1946), American baseball pitcher, nicknamed "Spaceman"

William C. Lee (1895–1948), American Army soldier and general

Bill Lee (author), Chinese American writer and ex-gang member

Billy Lee, baseball outfielder who played in the American League 1915-1916

Bill Lee (right-handed pitcher), baseball pitcher who played in the National League 1934-1947

William Lee

Bill Lee (musician), (born 1928), American jazz musician and composer

Bill Lee (Duke Power), ex-Chairman of the Board of Duke Power