Violeta Barrios de Chamorro (1929—), President of Nicaragua 1990–1996

Agustín Barrios (1885–1944), Paraguayan guitarist and composer

Miguel de Barrios (1625–1701), Jewish Spanish poet and historian, fled Spain during the Inquisition

Barrio, a district or neighborhood

Barrios Altos massacre, death squad massacre in Lima, Peru in 1991

Justo Rufino Barrios (1835–1885), President of Guatemala 1873–1885

Jorge Rodrigo Barrios (1976—), Argentine professional boxer

Paulo da Silva Barrios (1980—), Paraguyan professional football player

Los Barrios, town in the province of Cádiz in the Andalusia region of Spain

Puerto Barrios, city in Guatemala

Barrios Unidos, division of the city of Bogotá, Colombia

Francisco Barrios (1953–1982), Mexican-American professional baseball player

Fannie Barrios (1964–2005), Venezuelan bodybuilder

Jorge Walter Barrios (1961—), Uruguyan footballer, world cup 86

Jarrett Barrios (contemporary), American politician, state senator from Massachusetts

Arturo Barrios (born 1962), Mexican long-distance runner and former world record holder

Goizeder Victoria Azúa Barríos (contemporary), Venezuelan beauty queen

Pilar Barrios (1889–1974), Uruguyan poet of the black community

Eduardo Barrios (1884–1963), Chilean writer and poet

José María Reina Barrios (1854–1898), President of Guatemala 1892–1898

Carlos Jongitud Barrios (1924—), Mexican union leader and governor of San Luis Potosí

Fernando Gutiérrez Barrios (1927–2000), Mexican politician, head of the secret police, governor of Veracruz

Gerardo Barrios (1813–1865), President of El Salvador 1859–1863

Donald Barrios (contemporary), American businessman, assisted the work of the DEA

Alto Lucero de Gutiérrez Barrios, city in the Mexican state of Veracruz

Ciudad Barrios, municipality in the San Miguel department of El Salvador