Edward Victor Appleton, English physicist, known for his research on the ionosphere.

Appleton, Wisconsin, United States

Appleton, Minnesota, United States

Nathan Appleton, American merchant and politician

Appleton (music duo), a UK-based musical group with Canadian-born members.

Appleton Wiske, N Yorks, England

Natalie Appleton, British/Canadian singer

Nicole Appleton, British/Canadian singer

Appleton, Maine, United States

Appleton (crater), a lunar crater

Appleton's Cyclopedia of American Biography

William Appleton, former US Representative from Massachusetts

Appleton Thorn, Warrington, Cheshire, England

Alistair Appleton, British television presenter

Appleton, Newfoundland and Labrador, Canada

Appleton Estate, a Jamaican producer of rum.

Appleton, Oxfordshire, England

Victor Appleton, a house pseudonym, famous for the Tom Swift series.

Appleton Farms, a public park administered by the The Trustees of Reservations in Ipswich and Hamilton, Massachusetts, United States