Alexis de Tocqueville, a French political thinker and historian

Willibald Alexis, a German novelist

Alexisonfire, a band referred to as "Alexis" by fans

Alexis Bledel, an actress

Alexis I of Russia

Alexis Colby, of the TV show Dynasty

Alexis Rhodes, a character in the anime Yu-Gi-Oh! GX

Alexis Meade, a fictional character in the television series Ugly Betty

Alexis Arquette, American transgendered actor and musician, of the Arquette acting family

Alexis Denisof, an actor

Alexis (singer), a German pop singer

Paul Alexis, a French writer

Alexis, Illinois, USA

Alexis Christoforous a WCBS-TV Wall Street reporter

Patriarch Alexius I

Alexis Ruano Delgado, Spanish footballer

Alexis Dziena, an actress

Alexis Suárez Martín, a Spanish footballer, playing for Levante UD

Alexis (Eclogues), character in Eclogues II, beloved of Corydon

Alexis, a Greek comic poet

ALEXIS, acronym for the Array of Low Energy X-ray Imaging Sensors spacecraft

Alexis Malone, a porn actress

Alexis (country singer), a teenage singer featured on the Confessions of a Teenage Drama Queen soundtrack