Pedro Bravo de Acuña (d. 1606), Spanish military officer and colonial official in the New World and the Philippines

Manuel Acuña Roxas (1892–1948), President of the Philippines 1946–1948

Diego Sarmiento de Acuña, conde de Gondomar (1567–1626), Spanish diplomat and ambassador

Marcela Acuña (1976—), Argentine female boxer

Ciudad Acuña or Villa Acuña, city in the state of Coahuila, Mexico

Juan de Acuña, marqués de Casafuerte (1658–1734), Spanish military officer and viceroy of New Spain 1722–1734

Roberto Acuña (1972—), Paraguyan professional football player

Clarence Acuña (1975—), Chilean professional football player

Antonio Osorio de Acuña (1459–1526), Spanish bishop of Zamora

Jason Acuña (1973—), American skateboarder and television host

Alex Acuña (1944—), Peruvian drummer and percussionist

Francisco Javier González-Acuña (contemporary), Mexican mathematician, professor, and author

Cristóbal Diatristán de Acuña (1597–1676), Spanish missionary and explorer

Ricardo Acuña (1958—), Chilean champion tennis player

Ing. Alberto Acuña Ongay International Airport, serving Campeche, Mexico

Hernando de Acuña (1520–1580), Spanish poet and translator in the court of Charles V

Francisco Acuña de Figueroa (1790–1862), Uruguayan poet

Luisa Acuna (1899–[?]), Filipina actress

Fely Acuna (1936—), Filipina actress

Alicia Acuna (contemporary), American news reporter on the Fox News Channel