Acne vulgaris, a skin condition originally called acme in Greek, but whose spelling has been corrupted

Acme (Greek: ακμή, the peak, zenith, prime) denotes the best of something. Acme may also refer to:

ACME and V.I.L.E., a fictional detective agency from the Carmen Sandiego series of computer games and television shows

Acme Corporation (A Company that Makes Everything), a fictional company in the cartoon world of Looney Tunes

Acme Brick Company, a brick manufacturer that is a subsidiary of Berkshire Hathaway

Acme, Michigan, USA

Acme Township, Michigan, USA

Acme Novelty Library, a comic book by cartoonist Chris Ware and published by Fantagraphics Books

Acme Markets, a chain of grocery stores in the northeastern United States

Acme Fresh Market, a chain of grocery stores in Akron, Ohio, USA

Acme Boots, a manufacturer of western footwear owned by Berkshire Hathaway

Acme, Alberta, Canada

Acme, Washington, USA

Acme (text editor) is a text editor and development environment originally for the Plan 9 from Bell Labs operating system

Acme thread form, a screw thread used in specialized applications such as vises and leadscrews

ACME Communications, a television broadcasting company, based in Santa Ana, USA

Acme Whistles, a major producer of whistles

Acme (automobile), an automobile built between 1903–1911 in Reading, Pennsylvania

Acme Township, North Dakota, USA

Acme Packet, a VoIP Session Border Controller manufacturer

ACME (album), the sixth album by the Jon Spencer Blues Explosion

Air Craft Marine Engineering, an aircraft designer based in Van Nuys, California, USA during the 1950s

Acme Aircraft Corporation, an aircraft manufacturer based in Rockford, Illinois, USA during the 1920s

Acme (ADL), an architecture description language by Carnegie Mellon University

Acme Records, an independent record label

Acme Industrial Hardware Trading L.L.C., a shelving and material handling equipment supplier in Dubai, United Arab Emirates

Acme-Nuage Systems a shelving and material handling equipment supplier in Bangalore, India

ACME (Apache, ColdFusion, MySQL and Eclipse_(software). Open Source Development with Apache, Adobe ColdFusion, MySQL and Eclipse. See [1].