In the following essay, Garber traces Descartes' approach to science and scientific practice from the Regulae to the Principia Philosopiae, contending that Descartes abandoned his early philosophy that science must be deductively certain, instead nearly coming to the conclusion that science relies on hypothetical arguments and experimentation.

In the following essay, Clarke examines the epistemological and metaphysical underpinnings of Descartes' philosophy of science, contrasting it with scholasticism.

In the essay that follows, Larmore contends that Descartes' epistemology uses experimentation within a framework of a priori principles to advance human knowledge.

In the following essay, Burtt examines Descartes' mathematical conception of nature and his motives for proposing a mind-body dualism.

In the essay that follows, Beyssade examines the paradoxical claims that form the basis of Descartes' metaphysics: that God is incomprehensible and that, to know anything, one must have a clear and distinct understanding of God.