In the following review, Rhodes asserts that Lost Highway's narrative is based on a theme-and-variation structure in which recurrent visual and thematic motifs take precedence over conventional narrative coherence.

In the following review, Warner examines the doppelgänger motif of Lost Highway as a metaphor for identity crisis in the modern world, but concludes that Lynch's treatment of this theme is ultimately lacking in substance.

In the following interview, Lynch discusses Lost Highway and his creative process.

In the following review, Newman assesses Lost Highway as a “noir horror film.”