Of Mice and Men is a short novel in six scenes presented in description-dialogue-action form that approximates stage drama in its effect…. The time scheme runs from Thursday evening through Sunday evening—exactly three days in sequence, a matter of some importance, as we shall see presently. The setting is the Salinas Valley in California, and most of the characters are unskilled migratory workers who drift about the villages and ranches of that area picking up odd jobs or doing short-term field work and then moving on to the next place of employment. Steinbeck focuses on two such laborers who dream of one day saving up enough money to buy a small farm of their own. (p. 124)
The title of the story has a two-fold application and significance. First it refers to naturalistic details within the texture of the novella: Lennie likes to catch mice and stroke their fur with his fingers. This is a particularly important point for two reasons: it establishes Lennie's fatal weakness for stroking soft things and, since he invariably kills the mice he is petting, it foreshadows his deadly encounter with Curley's wife. Secondly, the title is of course a fragment from the poem by Robert Burns ["The best laid schemes o' mice an' men/Gang aft agley."], which gives emphasis to the idea of the futility of human endeavor or the vanity of human wishes…. This notion is obviously of major importance in the novella, and it may be said to be Steinbeck's main theme on the surface level of action and development of character. (p. 125)
